[paper accepted] Quantitative Evaluation of Peptide-Material Interactions by a Force Mapping Method: Guidelines for Surface Modification

Title: “Quantitative Evaluation of Peptide-Material Interactions by a Force Mapping Method: Guidelines for Surface Modification” Author(s): Mochizuki, Masahito; Oguchi, Masahiro; Kim, Seong-Oh; Jackman, Joshua; Ogawa, Tetsu; Lkhamsuren, Ganchimeg; Cho, Nam-Joon; Hayashi, Tomohiro This article has just accepted for the publication in Langmuir. [link to the article]  

Nanobio small workshop

We had a small “nanobio workshop” with inviting three speakers: 11:00-11:15 研究会の趣旨説明 (林) Introduction (Hayashi) 11:15-12:15 手老 龍吾 先生 (豊橋科学技術大学 エレクトロニクス先端融合研究所) 「支持平面脂質二重膜内の分子拡散および構造への固体基板表面の影響」 Prof. Ryugo Tero (Toyohasi Univ. of Tech.) “Molecular diffusion in supported lipid bilayers and effect of physicochemical properties of solid surfaces on the behavior of the lipid molecules 13:30-14:30 住友 弘二 先生 (NTT物性科学基礎研究所) 「膜タンパク質で機能するナノバイオデバイス」 Dr. Koji Sumitomo (NTT Basic research lab) “Nanobio devices using membrane proteins” 14:30-14:45 休憩 14:45-16:05 望月 祐志 先生 (立教大学理学部化学科) 「フラグメント分子軌道(FMO)法の概要、応用事例と今後の展開」 Prof. Yuji Mochizuki (Dep. Chem. Rikkyo University) “Fragment molecular orbital method: applications and upcoming projects”


以下の総説の発表が決まりました。 単分子膜における生体不活性特性のメカニズム: 分子集積密度の界面水分子の振る舞いへの影響 関根泰斗1・Syifa Asatyas1・丹生隆1・Ganchimeg Lkhamsuren1・角井杏帆1・佐藤千香子2・森田成昭3・田中賢2・林智広1,* 1東京工業大学大学院 総合理工学研究科 物質電子化学専攻 〒226-8502 神奈川県横浜市緑区長津田町4259 2山形大学大学院 理工学研究科 バイオ化学工学専攻 〒992-8510 山形県米沢市城南四丁目3-16 3大阪電気通信大学 工学部 基礎理工学科〒572-8530 大阪府寝屋川市初町18-8 Intercorrelation between interfacial behavior of water and biocompatibility We investigated the substrate-dependence of bioinertness of self-assembled monolayers of methoxy-tri(ethylene glycol)-terminated alkanethiol (EG3-OMe SAMs). Our surface force measurements revealed that strong water-induced repulsion operated between bioinert Au-supported EG3-OMe SAM. In contrast, there was no such repulsion observed for a bio-adhering Ag-supported EG3-OMe SAM. Surface-enhanced infrared absorption spectra showed that state of hydrogen bondings between interfacial water molecules near the EG3-OMe SAMs are different depending on the substrates. These results clearly indicate that interfacial water plays a key role in the bioinertness of the SAMs.