以下の総説の発表が決まりました。
単分子膜における生体不活性特性のメカニズム:
分子集積密度の界面水分子の振る舞いへの影響
関根泰斗1・Syifa Asatyas1・丹生隆1・Ganchimeg Lkhamsuren1・角井杏帆1・佐藤千香子2・森田成昭3・田中賢2・林智広1,*
1東京工業大学大学院 総合理工学研究科 物質電子化学専攻 〒226-8502 神奈川県横浜市緑区長津田町4259
2山形大学大学院 理工学研究科 バイオ化学工学専攻 〒992-8510 山形県米沢市城南四丁目3-16
3大阪電気通信大学 工学部 基礎理工学科〒572-8530 大阪府寝屋川市初町18-8
Intercorrelation between interfacial behavior of water and biocompatibility
We investigated the substrate-dependence of bioinertness of self-assembled monolayers of methoxy-tri(ethylene glycol)-terminated alkanethiol (EG3-OMe SAMs). Our surface force measurements revealed that strong water-induced repulsion operated between bioinert Au-supported EG3-OMe SAM. In contrast, there was no such repulsion observed for a bio-adhering Ag-supported EG3-OMe SAM. Surface-enhanced infrared absorption spectra showed that state of hydrogen bondings between interfacial water molecules near the EG3-OMe SAMs are different depending on the substrates. These results clearly indicate that interfacial water plays a key role in the bioinertness of the SAMs.
