Why do saccharide surfaces resist nonspecific protein adsorption? We studied glucose-, lactose- and maltose-terminated self-assembled monolayers (SAMs) and found saccharide-dependent protein resistance (maltose > lactose > glucose). Surface force measurements revealed short-range repulsion caused by structured interfacial water, which was closely linked to the observed selectivity in protein adsorption.
Zhentao Zhao, Tomohiro Hayashi. “Written in Water: Hydration Repulsion Governs Selective Protein Adsorption on Saccharide Self-Assembled Monolayers”. Langmuir (2026).
Links
- Journal: Langmuir (2026) DOI: 10.1021/acs.langmuir.6c02346
