[paper accepted] Surface arginine and protein corona formation on anti-fouling surfaces

The protein corona determines the biocompatibility of medical devices. Using quantitative proteomics (nano LC-MS/MS), we identified more than 200 serum proteins adsorbed on each of six model organic surfaces. Conventional descriptors such as isoelectric point and molecular weight did not explain which proteins were enriched on non-fouling films, whereas the fraction of surface arginine was correlated with enrichment.

Ayano Nomura, Guanghao Hu, Ang Art Wei Yao, Chisato Komura, Hideharu Kurioka, Tomohiro Hayashi. “Chaotropic Surface Arginine Correlates With Protein Corona Formation on Anti‐Fouling Biomaterial Surfaces: A Quantitative Proteomics and Protein Structure Study”. Advanced Materials Interfaces (2026).