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Stochastic binding process of blunt-end stacking of DNA molecules observed by atomic force microscopy. Sekine, T.; Kanayama, N.; Ozasa, K.; Nyu, T.; Hayashi, T.; Maeda, M.  Langmuir 2018. 

Molecular-scale structures of surface and hydration of bioinert mixed-charged self-assembled monolayers investigated by frequency modulation atomic force microscopy. Araki, Y.; Sekine, T.; Chang, R.; Hayashi, T.; Onishi, H.  RSC Advances 2018. 

Application of fuzzy logic algorithm to single-molecule force spectroscopy of the streptavidin-biotin system.
Tahara, H.; Nyu, T.; Mondarte, E. A. Q.; Maekawa, T.; Hayashi, T. Advances in Materials Physics and Chemistry in print 2018.

Water near bioinert self-assembled monolayers. Chang, R.; Asatyas, S.; Lkhamsuren, G.; Hirohara, M.; Mondarte, E. A. Q.; Suthiwanich, K.; Sekine, T.; Hayashi, T.  Polym. J. (Tokyo, Jpn.) 2018. 

Well-Ordered Domains of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111) Guided by a Displacement Reaction. Sung, T.; Seong, S.; Han, S.; Son, Y. J.; Ishida, T.; Hayashi, T.; Hara, M.; Noh, J.  J. Nanosci. Nanotechnol. 2018, 18. 

[談話室] 林研究室の紹介: 研究内容・研究室内コミュニケーションについて. 林智広.  応用物理学会 薄膜・表面物理分科会 News Letter 2018, 162, 40-44. 


田原寛之; Kwaria, R. J.; 林智広. マテリアルズ・インフォマティクス; 技術情報協会 2018.

田原寛之; Kwaria, R. J.; 林智広. マテリアルズ・インフォマティクス~データ科学と計算・実験の融合による材料開発~ 8 「マテリアルズ・インフォマティクスを用いたバイオマテリアルの設計の現状と今後の展開; 情報機構 2018.


生体適合性をもつ単分子膜~表面・界面科学の手法を利用したメカニズムの解明~. 張嶺碩; 関根泰斗; Asatyas, S.; Lkhamsuren, G.; 大橋智幸; 林智広. 化学工業 2017, 68 (12), 886.

Well-Ordered Domains of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111) Guided by a Displacement Reaction. Sung, T.; Seong, S.; Han, S.; Son, Y. J.; Ishida, T.; Hayashi, T.; Hara, M.; Noh, J. J. Nanosci. Nanotechnol. 2017.

Damage-free tip-enhanced Raman spectroscopy for heat-sensitive materials. Mochizuki, M.; Lkhamsuren, G.; Suthiwanich, K.; Mondarte, E. A.; Yano, T. A.; Hara, M.; Hayashi, T.  Nanoscale 2017, in print.


Fabrication of mechanically stable Au-coatings on probes of atomic force microscopes for nano-mechanical and -optical measurements. Lkhamsuren, G.; Mochizuki, M.; Suthiwanich, K.; Hayashi, T.  Thin Solid Films 2017, 636, 478-484.


Raman imaging analysis of local crystal structures in LiCoO2 thin films calcined at different temperature. Hara, K.; Yano, T.; Suzuki, K.; Hirayama, M.; Hayashi, T.; Kanno, R.; Hara, M.  Anal. Sci. 2017, 33 (7), 853-858.


Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: mechanisms underlying the effect of lateral packing density on bioinertness. Sekine, T.; Asatyas, S.; Sato, C.; Morita, S.; Tanaka, M.; Hayashi, T.  J Biomater Sci Polym Ed 2017, 1-13.

Formation and Structural Changes of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111). Han, M.-S.; Ku, K.; Kang, H.; Ohashi, R.; Hayashi, T.; Hara, M.; Noh, J.  Jounal of Nanosicence and Nanotechnology 2017, 17 (8), 5597-5600.


Standing-Up Phase of Hexanedithiol Self-Assembled Monolayers on Au(111) Induced by Displacement Reaction. Han, M.-S.; Ku, K.; Kang, H.; Ohashi, R.; Hayashi, T.; Hara, M.; Noh, J.  Jounal of Nanosicence and Nanotechnology 2017, 17 (8), 5780-5783.



Laser-scanning-assisted tip-enhanced optical microscopy for robust optical nano-spectroscopy. Yano, T.-a.; Tsuchimoto, Y.; Mochizuki, M.; Hayashi, T.; Hara, M. Appl. Spectrosc. 2016, 70 (7), 1239-1243.

Fano resonant all-dielectric core/shell nanoparticles with ultrahigh scattering directionality in the visible region. Tsuchimoto, Y.; Yano, T.-a.; Hayashi, T.; Hara, M. Opt. Lett. 2016, 24 (13), 14451-14462.


Thiol molecules as temperature sensors for surface-enhanced Raman scattering measurements of heat-sensitive materials. Mochizuki, M.; Asatyas, S.; Suthiwanich, K.; Hayashi, T. Chem. Lett. 2016, in print.

Striped Phase of 3-Hexylthiophene Self-Assembled Monolayers on Au(111) from Vapor Phase Deposition. Kim, Y.; Kang, H.; Tsunoi, A.; Hayashi, T.; Hara, M.; Noh, J. J. Nanosci. Nanotechnol. 2016, 16 (3), 2792-2795.

Correlating single-molecule and ensemble-average measurements of peptide adsorption onto different inorganic materials. Kim, S. O.; Jackman, J. A.; Mochizuki, M.; Yoon, B. K.; Hayashi, T.; Cho, N. J. Phys. Chem. Chem. Phys. 2016, 18 (21), 14454-9. 10.1039/c6cp01168c

Effect of Solution Concentration on the Formation of Ordered Domains in Pentachlorobenzenethiol Self-Assembled Monolayers on Au(111). Kang, H.; Ito, E.; Hayashi, T.; Hara, M.; Noh, J. J. Nanosci. Nanotechnol. 2016, 16 (6), 6360-6363.

Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force. Kanayama, N.; Sekine, T.; Ozasa, K.; Kishi, S.; Nyu, T.; Hayashi, T.; Maeda, M. Langmuir 2016. in print

Comparative Study for Displacement of Cyclohexanethiolate and Cyclohaxaneselenolate Self-Assembled Monolayers on Au(111) by Octanethiols. Jeong, H.; Kang, H.; Han, S.; Park, H.; Han, J.; Hayashi, T.; Hara, M.; Noh, J. J. Nanosci. Nanotechnol. 2016, 16, 8508-8512.

Formation and Structure of Self-Assembled Monolayers by Adsorption of Octaneselenocyanate on Au(111). Han, S.; Kang, H.; Park, J. B.; Hayashi, T.; Hara, M.; Noh, J. J. Nanosci. Nanotechnol. 2016, 16, 8610-8613.

Surface force analysis of pyrite (FeS2): its reactivity to amino acid adsorption. Ganbaatar, N.; Matsuzaki, N.; Nakazawa, Y.; Afrin, R.; Aono, M.; Yano, T.-a.; Hayashi, T.; Hara, M. Advances in Materials Physics and Chemistry 2016. 10.4236/ampc.2016.67018


単分子膜における生体不活性特性のメカニズム: 分子集積密度の界面水分子の振る舞いへの影響

. 関根泰斗; Asatyas, S.; 丹生隆; Lkhamsuren, G.; 角井杏帆; 佐藤千香子; 森田成昭; 田中賢; 林智広. 表面科学 2015, 36 (8), 424-429.

Probing edge-activated resonant Raman scattering from mechanically exfoliated 2D MoO3 nanolayers. Yano, T. A.; Yoshida, K.; Hayamizu, Y.; Hayashi, T.; Ohuchi, F.; Hara, M. 2d Materials 2015, 2 (3), 035004. Artn 035004


Controlling the Visible Electromagnetic Resonances of Si/SiO2 Dielectric Core-Shell Nanoparticles by Thermal Oxidation. Tsuchimoto, Y.; Yano, T. A.; Hada, M.; Nakamura, K. G.; Hayashi, T.; Hara, M. Small 2015, 11 (37), 4844-9. 10.1002/smll.201500884

Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Mono layers with a Chemical Gradient. Sekine, T.; Tanaka, Y.; Sato, C.; Tanaka, M.; Hayashi, T. Langmuir 2015, 31 (25), 7100-7105. 10.1021/acs.langmuir.5b01216

Quantitative Evaluation of Peptide-Material Interactions by a Force Mapping Method: Guidelines for Surface Modification. Mochizuki, M.; Oguchi, M.; Kim, S. O.; Jackman, J. A.; Ogawa, T.; Lkhamsuren, G.; Cho, N. J.; Hayashi, T. Langmuir 2015, 31 (29), 8006-12. 10.1021/acs.langmuir.5b01691

Calixarene-polymers via Simple Polymerization of <i>t</i>-Butylcalix[8]arenes (A<sub>8</sub>-type Monomer) with Hexamethylene Diisocyanate (B<sub>2</sub>-type Monomer); Molecular Bunch of Grapes (Botryosin). Kudo, H.; Shizuma, M.; Kubo, K.; Hayashi, T. Chem. Lett. 2015, 44 (12), 1765-1767. 10.1246/cl.150840

Tip-enhanced THz Raman spectroscopy for local temperature determination at the nanoscale. Balois, M. V.; Hayazawa, N.; Catalan, F. C.; Kawata, S.; Yano, T. A.; Hayashi, T. Anal. Bioanal. Chem. 2015, 407 (27), 8205-13. 10.1007/s00216-015-8866-0


血液適合性に優れた高分子材料の水和状態. 田中賢; 林智広; 森田成昭. バイオマテリアル 2014, 32 (2), 74-85.

林智広. 表面科学の基礎 (現代表面科学シリーズ 2); 共立出版2014.

林智広. 走査型プローブ顕微鏡によるバイオマテリアルの解析. In 生体適合性制御と要求特性掌握から実践する高分子バイオマテリアルの設計・開発戦略

~モノマー(いち)からデザインするバイオインターフェースと上市までの道筋~; サイエンス&テクノロジー: Tokyo, 2014.

Spectral tunability of realistic plasmonic nanoantennas. Portela, A.; Yano, T.; Santschi, C.; Matsui, H.; Hayashi, T.; Hara, M.; Martin, O. J. F.; Tabata, H. Appl. Phys. Lett. 2014, 105 (9), 91105-91110. Artn 091105

Doi 10.1063/1.4894633

Light-transmittable Ultrasmooth Gold Film for Gap Mode Tip-Enhanced Raman Scattering Spectroscopy. Oguchi, M.; Mochizuki, M.; Yano, T.-a.; Hara, M.; Hayashi, T. Chem. Lett. 2014, 43 (6), 808-810. 10.1246/cl.140093

Effect of the distribution of adsorbed proteins on cellular adhesion behaviors using surfaces of nanoscale phase-reversed amphiphilic block copolymers. Hiraguchi, Y.; Nagahashi, K.; Shibayama, T.; Hayashi, T.; Yano, T.; Kushiro, K.; Takai, M. Acta Biomaterialia 2014, 10 (7), 2988-2995. Doi 10.1016/J.Actbio.2014.03.019


生体不活性特性における水分子の役割. 林智広. C & I Commun 2013, 38 (2), 17-18.

原子間力顕微鏡を用いた生体不活性表面近傍の水分子の解析. 小出裕基; 久保光亮; 関根泰斗; 水下佳紀; Ganbaatar, N.; 林智広. 表面科学 2013, 34 (9), 494-499.

The Roles of Water Molecules at the Biointerface and Application of Medical Polymers. Tanaka, M.; Hayashi, T.; Morita, S. Polym. J. (Tokyo, Jpn.) 2013, 45 (7), 701-710. 10.1038/pj.2012.229

Subtractive offset printing for fabrication of sub micrometer scale electrodes with gold nanoparticles. Tanaka, M.; Mabuchi, Y.; Hayashi, T.; Hara, M. Microelectron. Eng. 2012, 95 (15), 14-20. 10.1016/j.mee.2012.02.023

Temperature-modulated adsorption of poly(N-isopropylacrylamide)-grafted ferritin on solid substrate. Kumashiro, Y.; Ikezoe, Y.; Hayashi, T.; Okabayashi, Y.; Tamada, K.; Yamato, M.; Okano, T.; Hara, M. Colloids Surf B Biointerfaces 2012, 95, 57-64. 10.1016/j.colsurfb.2012.02.028

Influence of Surface Morphology and Substrate on Thermal Stability and Desorption Behavior of Octanethiol Self-Assembled Monolayers: Cu, Ag, and Au. Ito, E.; Ito, H.; Kang, H.; Hayashi, T.; Hara, M.; Noh, J. J. Phys. Chem. C 2012, 116 (33), 17586-17593. Doi 10.1021/Jp3041204

Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: protein adsorption, platelet adhesion, and surface forces. Hayashi, T.; Tanaka, Y.; Koide, Y.; Tanaka, M.; Hara, M. Phys. Chem. Chem. Phys. 2012, 14 (29), 10196-206. 10.1039/c2cp41236e

バイオ界面における水分子の役割は?-次世代医療を切り開く生体親和性材料-. 田中賢; 林智広; 森田成昭. 化学 2011, 66 (5), 68-69.

Tamada, K.; Li, X.; Wulandari, P.; Nagahiro, T.; Michioka, K.; Toma, M.; Toma, K.; Obara, D.; Nakada, T.; Hayashi, T.; Ikezoe, Y.; Hara, M.; Katano, S.; Uehara, Y.; Kimura, Y.; Niwano, M.; Tero, R.; Okamoto, K. Fabrication and Application of Plasmonic Silver Nanosheet; Springer2011. p 139-157.

Nonfouling self-assembled monolayers: mechanisms underlying protein and cell resistance. Hayashi, T.; Hara, M. Current Physical Chemistry 2011, 1 (2), 90-98.

Nanoscale Chemical Composition Analysis Using Peptides Targeting Inorganic Materials. Arai, Y.; Okabe, K. I.; Sekiguchi, H.; Hayashi, T.; Hara, M. Langmuir 2011, 27 (6), 2478-2483. Doi 10.1021/La104178h

生体分子をプローブとした表面の化学組成分析. 林智広; 新井勇貴; 原正彦. Molecular Electronics and Biolectronics 2010, 21 (2), 73-78.

Ag nanoparticle sheet as a marker of lateral remote photocatalytic reactions. Nagahiro, T.; Ishibashi, K.; Kimura, Y.; Niwano, M.; Hayashi, T.; Ikezoe, Y.; Hara, M.; Tatsuma, T.; Tamada, K. Nanoscale 2010, 2, 107-113.

生体分子の吸着忌避特性を持つ表面が引き起こすナノメートルスケールの相互作用. 林智広; 田中勇作; 原正彦. 表面科学 2009, 30, 444-447.

Quantitative study of the gold-enhanced fluorescence of CdSe/ZnS nanocrystals as a function of distance using an AFM probe. Lee, S. Y.; Nakaya, K.; Hayashi, T.; Hara, M. Phys. Chem. Chem. Phys. 2009, 11 (21), 4403-4409. Doi 10.1039/B819903e

Blinking Kinetics of Single CdSe/ZnS Nanocrystals by Photon-Counting Statistics at High Temporal Resolution. LEE, S. Y.; Isoshima, T.; HAYASHI, T.; HARA, M. e-Journal of Surface Science and Nanotechnology 2009, 7, 701-707.

Effect of Steric Hindrance on Desorption Processes of Alkanethiols on Au(111). Hayashi, T.; Wakamatsu, K.; Ito, E.; Hara, M. J. Phys. Chem. C 2009, 113, 18795-18799.

Behavior of Hydroxide Ions in Vicinity of Self-Assembled Monolayers of Alkanethiols on Metals. Hayashi, T.; Tanaka, Y.; Usukura, H.; Hara, M. e-Journal of Surface Science and Nanotechnology 2009, 7, 601-605.

Critical Amino Acid Residues for the Specific Binding of the Ti-Recognizing Recombinant Ferritin with Oxide Surfaces of Titanium and Silicon. Hayashi, T.; Sano, K. I.; Shiba, K.; Iwahori, K.; Yamashita, I.; Hara, M. Langmuir 2009, 25 (18), 10901-10906. Doi 10.1021/La901242q

Self-Assembled Monolayers with Chemical Gradients: Fabrication and Protein Adsorption Experiments. Hayashi, T.; Makiuchi, N.; Hara, M. Japanese Journal of Applied Physics 2009, 48, 095503-095507.

Au(111)表面上におけるシクロデキストリン末端基を持つチオール分子の吸着プロセス: 立体障害を持つ分子を高秩序配列させるためには. 林智広; 熊谷悠記; 熊代善一; 齋藤公良; 原正彦. 表面科学 2008, 29 (8), 495-497.

Superperiodic assembly of 2,6-diethynylpyridine through weak hydrogen bonds at the 1-phenyloctane/HOPG interface. Otsuki, J.; Arai, Y.; Amano, M.; Sawai, H.; Ohkita, M.; Hayashi, T.; Hara, M. Langmuir 2008, 24 (11), 5650-5653. Doi 10.1021/La8003036

原子間力顕微鏡を用いた無機物認識ペプチドのターゲット認識メカニズムの解明. 林智広; 佐野健一; 芝清隆; 岩堀健治; 山下一郎; 原正彦. 表面科学 2007, 28 (7), 391-396.

金属薄膜標準物質の現状,ニーズ,技術背景に関する報告. 林智広. AIST BULLETIN OF METROLOGY 2007, 6 (1), 61-68.

Direct observation of interaction between proteins and blood-compatible polymer surfaces. Hayashi, T.; Tanaka, M.; Yamamoto, S.; Shimomura, M.; Hara, M. Biointerphases 2007, 2 (4), 119-125. Doi 10.1116/1.2794712

走査型プローブ顕微鏡の可能性. 原正彦; Wang, T.; 林智広. 生体の科学 2006, 57 (4), 287-291.

Selective nanoscale positioning of ferritin and nanoparticles by means of target-specific peptides. Yamashita, Y.; Kirimura, H.; Okuda, M.; Nishio, K.; Sano, K. I.; Shiba, K.; Hayashi, T.; Hara, M.; Mishima, Y. Small 2006, 2 (10), 1148-1152. Doi 10.1002/Smll.200600220

Fabrication of COOH-terminated self-assembled monolayers for DNA sensors. Nakamura, F.; Ito, E.; Hayashi, T.; Hara, M. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2006, 284-285, 495-498. 10.1016/j.colsurfa.2005.10.088

Mechanism underlying specificity of proteins targeting inorganic materials. Hayashi, T.; Sano, K.; Shiba, K.; Kumashiro, Y.; Iwahori, K.; Yamashita, I.; Hara, M. Nano Lett. 2006, 6 (3), 515-519. Doi 10.1021/Nl050050n

Long-Ranged and Short-Ranged Electrostatic Interaction Between Modified Silicon Surfaces and Recombinant Ferritin Molecules. Hayashi, T.; Hara, M. Japanese Journal of Applied Physics 2005, 44 (7B), 5374-5377. 10.1143/jjap.44.5374

吸光・蛍光材料の表面プラズモン分光法と電極界面への応用可能性. 栗原一嘉; 林智広; 原正彦. Review of Polarography 2004, 50 (3), 183.

Interaction of water with self-assembled monolayers: Neutron reflectivity measurements of the water density in the interface region. Schwendel, D.; Hayashi, T.; Dahint, R.; Pertsin, A.; Grunze, M.; Steitz, R.; Schreiber, F. Langmuir 2003, 19 (6), 2284-2293. Doi 10.1021/La026716k

チオール系自己組織化膜の第一原理分子動力学シミュレーション. 森川良忠; 林智広; 劉子敬; 野副尚一. 表面科学 2002, 23, 423-430.

Grand canonical Monte Carlo Simulations of the hydration interaction between oligo(ethylene glycol)-terminated alkanethiol self-assembled monolayers. Pertsin, A. J.; Hayashi, T.; Grunze, M. J. Phys. Chem. B 2002, 106 (47), 12274-12281. Doi 10.1021/Jp0257471

First-principles theoretical study of alkylthiolate adsorption on Au(111). Morikawa, Y.; Hayashi, T.; Liew, C. C.; Nozoye, H. Surf. Sci. 2002, 507, 46-50. Pii S0039-6028(02)01173-1

Grand canonical Monte Carlo simulation of hydration forces between nonorienting and orienting structureless walls. Hayashi, T.; Pertsin, A. J.; Grunze, M. J. Chem. Phys. 2002, 117 (13), 6271-6280. Doi 10.1063/1.1504436

The interaction of oligo(ethylene glycol) with water: Testing an atomistic force field for transferability. Pertsin, A. J.; Hayashi, T.; Grunze, M. Phys. Chem. Chem. Phys. 2001, 3 (9), 1598-1601.

Decomposition of alkanethiols adsorbed on Au (111) at low temperature. Kodama, C.; Hayashi, T.; Nozoye, H. Appl. Surf. Sci. 2001, 169, 264-267.

Adsorption state of dimethyl disulfide on Au(111): Evidence for adsorption as thiolate at the bridge site. Hayashi, T.; Morikawa, Y.; Nozoye, H. J. Chem. Phys. 2001, 114 (17), 7615-7621.

Structural evolution of dibutyldisulfide adsorbed on Au(111). Hayashi, T.; Kodama, C.; Nozoye, H. Appl. Surf. Sci. 2001, 169, 100-103.

Adsorption state of diethyldisulfide on Au(111) studied with a combined system of HREELS and STM. Hayashi, T.; Fricke, A.; Katsura, K.; Kodama, C.; Nozoye, H. Surf. Sci. 1999, 428, 393-397.